A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis.

A POP1 repressor complex restricts inappropriate cell typespecific gene transcription during Caenorhabditis elegans embryogenesis

pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos

In C. elegans embryogenesis, the MS blastomere produces predominantly mesodermal cell types, while its sister E generates only endodermal tissue. We show that a maternal gene, pop-1, is essential for the specification of MS fate and that a mutation in pop-1 results in MS adopting an E fate. Previous studies have shown that the maternal gene skn-1 is required for both MS and E development and th...

Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1.

Lymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that mediate the Wnt signaling pathway, and have crucial roles during embryonic development in various organisms. Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export. We identify three lysines that a...

pop-l Encodes an HMG Box Protein Required for the Specification of a Mesoderm Precursor in Early C. elegans Embryos

In C. elegans embryogenesis, the MS blastomere produces predominantly mesodermal cell types, while its sister E generates only endodermal tissue. We show that a maternal gene, pop-l, is essential for the specification of MS fate and that a mutation in pop-l results in MS adopting an E fate. Previous studies have shown that the maternal gene skn-7 is required for both MS and E development and th...

C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels.

Canonical Wnt signaling converts the TCF/LEF transcription factor from repressor to activator by increasing nuclear levels of its coactivator, beta-catenin. A striking exception had been reported for Wnt-induced endoderm formation during C. elegans embryogenesis. It has long been believed that transcriptional activation of Wnt target genes in the endoderm precursor occurred due to a lowering of...